Toxicology

Once a compound is selected for drug development, its therapeutic potential for humans is established by evaluating safety and toxicity in animal models. Experienced Ricerca professionals help you choose the study parameters (dose rate, animal species, route of administration and animal population distribution) and protocol. Our expertise in conducting studies and developing the requisite data package and reports for IND submission can help ensure the success of potential candidates.

Typically, we perform 14- or 28-day toxicity studies in two or more animal species. A variety of dosing regimens is supported, including extended-duration studies for chronic dosing regimens. Strong, on-site bioanalytical support ensures good toxicokinetic and dose solution stability data.

Ricerca’s toxicology services include: 

• Toxicokinetic and pharmacokinetic studies 

• General toxicology

• Single dose and repeated dose

• Developmental and reproductive (DART)

• Long-term and sub-chronic

• Juvenile toxicology

• Genotoxicology

• Immunotoxicology

• Carcinogenicity

• Neurotoxicity

• Local tolerance

• In vitro assays