CAREERS

Ricerca Biosciences is a premier provider of collaborative preclinical drug development services to the pharmaceutical industry. Ricerca's current product offering is unique among preclinical development service companies. We provide an integrated approach with biology and chemistry on one site. This allows Ricerca to offer the only integrated drug development solution between discovery and IND filing in the market.

CAREER OPPORTUNITIES

DMPK SCIENTIST/SR. SCIENTIST/SECTION HEAD/or SR. MANAGER

The ideal candidate will have a Ph.D. in pharmacology, biology or biochemistry along with 5-10 years industrial drug discovery experience emphasizing pharmacokinetics; development experience is a plus but not necessary. The successful candidate should have technical experience with in vivo studies, PK analysis and interpretation as well as working knowledge of PK software such as WinNonlin (Pharsight Corp). The candidate should have experience managing a technical staff, possess good communication skills between clients and staff, good technical writing skills and project management skills.

STUDY DIRECTOR, TOXICOLOGY & PHARMACOLOGY

The responsibilities include development and coordination of a team of technicians and scientists in the design and conduct of discovery and development pre-IND enabling toxicology studies in rodent and non-rodent species.

The candidate shall possess experience in developing and monitoring effective processes and scheduling through the use of resource scheduling software for optimum planning, execution and reporting of studies for clients.

The candidate shall possess excellent organizational and interpersonal skills, be a team player with strong communication management, presentation and solving toxicology issues as a member of our integrated project team.

Required qualification is a Ph.D. in toxicology and/or pharmacology, or a closely related discipline. Experience in the pharmaceutical/biopharma industry and A.B.T. or A.B.V.T. certification possessing at least 5 years experience in a GLP environment is highly desirable. This position will report directly to the Director of Toxicology.

Preference will be given to candidates with experience at a CRO. Excellent communication and technical writing skills are required. We offer a competitive salary along with a comprehensive benefit plan.

BIOLOGY TECHNICIAN

The ideal candidate will be responsible for performing technical and husbandry duties according to SOPs and protocols.

The successful candidate will maintain logs, records and collect data according to FDA/EPA/GLP guidelines and conduct routine technical and experimental procedures according to SOPs and protocols. The ideal candidate must maintain a clean, safe work area and take all necessary personal precautions to promote safety. The candidate will be a motivated team player with excellent written, oral communication and computer skills and be available to perform weekend and holiday duties.

Required qualification is a minimum of a high school diploma; a B.S. in Biology is preferred. We offer a competitive salary along with a comprehensive benefit plan. For entry level candidates the starting salary is $25,000 - $27,500.

ANALYTICAL CHEMIST

The ideal candidate will lead salt and polymorph screening studies in support of preclinical drug development in a CRO environment. Experience in the physicochemical characterization of small molecules (DSC, TGA, XRPD, particle size, moisture sorption, hot-stage microscopy, solubility) is desired. The successful candidate will also provide support to related groups (process chemistry, engineering, QC/QA). The position may also provide solid-state guidance and mentoring to other scientists and cross-functional project teams.

The candidate should have experience in salt selection and polymorph screening, strong skills in physical chemical characterization/pre-formulation. Experience with automated equipment, formulation, and HPLC desirable but not required. The candidate should possess excellent written documentation and oral communication skills, familiarity with regulatory guidelines and the ability to manage multiple projects in dynamic environment.

Required qualifications are a B.S., M.S., or Ph.D. in Chemistry or related science with two or more years of relevant experience.

ANALYTICAL CHEMIST

The successful candidate will conduct HPLC experiments in support of GMP/GLP stability studies and in support of non-stability activities, both within established deadlines. The candidate will coordinate stability studies as the Principal Investigator/Study Director, write protocols, reports, SOPs and test methods.

Required qualification is a B.S. in Chemistry with 5-10 years experience in a GLP/GMP industrial environment.

ANALYTICAL CHEMIST

We have an immediate need for HPLC chromatographers to develop and qualify in-process methods in a cGMP environment and conduct method transfers and testing in support of stability studies. The successful candidates will have good analytical/troubleshooting skills, ability to work independently or as part of a team and provide timely communications to team members. A B.S. or equivalent experience in chemistry with 3+ years of industry experience is required.

In addition, we have an immediate need for a Lab Technician to assist in all phases of QC support of pharmaceutical operations. The successful candidate will assist in the testing of raw materials, intermediates and drug substances and provide laboratory support to a broad range of analytical chemists. An Associates Degree or equivalent experience required.

In Vitro ADME SCIENTIST

Successful candidates will hold a Ph.D. degree in Biochemistry or a related field of science with 3-5 years experience in drug metabolism. Responsibilities include development and implementation of protocols for the conduct of in vitro metabolism assays to support of our client’s drug discovery and development efforts. Experience with in vitro ADME (metabolic and plasma stability, permeability, protein binding and CYP assays), in vivo ADME (pharmacokinectics, toxicity) and bioanalytical methods (LC-MS/MS, HPLC) are desired. Preference will be given to candidates with experience at a CRO. Excellent communication and technical writing skills are required.

MASS SPECTROMETRIST

The ideal candidate shall be proficient in bioanalytical methods development and validation, in compliance with FDA guidelines using LC-MS/MS instrumentation and HPLC. Experience in the extraction of drug and metabolites from biological matrices utilizing broad knowledge of analytical chemistry complete with experience in wet chemistry, metabolism studies, metabolic pathways and structure elucidation. Working experience with GLP is required. Required qualification is a B.S. in Chemistry with a minimum of 8 years experience in Analytical Chemistry or a M.S. in Chemistry with a minimum 5 years experience in Analytical Chemistry or a Ph.D. in Analytical Chemistry with a minimum of 3 years experience operating LC-MS/MS instrumentation and HPLC.

MEDICINAL CHEMISTRY

The major responsibilities for the position include the development of projects in medicinal, combinatorial, and/or organic chemistry. Apply chemical synthesis techniques to analyze and develop new drug candidates. Design, execute and interpret experiments that contribute to project strategies. Prepare technical reports, summaries, protocols, and quantitative analyses. Responsible for identifying patentable inventions.

Requires Ph.D. in Medicinal, Organic or Combinatorial Chemistry with a minimum of 5 years of development experience. Background to include expertise in modern purification techniques, working knowledge of chromatographic and spectroscopic techniques including HPLC, NMR and IR interpretation/analysis.

SYNTHETIC CHEMISTRY

Synthetic Chemists with Ph.D. in Organic Chemistry and 5 or more years of relevant industrial experience, which should include new route development, process optimization, and custom preparations at the gram to kilogram scale. Familiarity with cGMP is required.

Process Chemists with BS or MS in Organic Chemistry with 5 or more years of laboratory and kilo laboratory scale synthesis, process optimization, and pilot plant support experience. Familiarity with cGMP is preferred.

CHEMICAL ENGINEERING

Chemical Process Development Engineers with BS or MS in Chemical Engineering and relevant pharmaceutical process development experience. Experience in lab-scale development and pilot-scale demonstration of process technology and the manufacture of chemical based products to support commercial development programs. Working knowledge of cGMP reg.

Qualified applicants should send a resume to: Human Resources Department, Ricerca Biosciences, 7528 Auburn Road, P.O. Box 1000, Concord, Ohio 44077 Fax: 440.350.7923 E-mail: Human Resources.