Oncology

In Vitro

Cytotoxicity Assays - More than 50 cell lines available

• Acute cytotoxicity in primary or transformed cell lines using Alamar Blue
• Proliferation assays by Alamar Blue and ³H-thymidine incorporation
• Cell Death ELISA analysis for apoptosis
• Caspase activity
• Inhibition of mitochondrial respiration in kidney preparations
• DNA laddering for apoptosis
• Red blood cell lysis

Angiogenesis

• HUVEC proliferation
• Tubule formation

Target-specific assays

• Enzyme assay development and screening
  (ie HDAC, DNA ligase, kinase)
• DNA intercalation
• Covalent binding
• Receptor binding
• Signaling pathways

• SCID or nude mouse tumor model using human tumor cell lines derived from leukemia, melanoma, lung, colon, brain, ovary, breast, prostate and kidney cancer cells
• Acute and rising dose toxicity (see Toxicology)
• Mutant or transgenic rodent models