Chemical Development Overview

The Single-Source Solution for Drug Discovery and Chemical Development

Ricerca provides complete analytical chemistry, synthetic chemistry, engineering and API manufacturing services designed to meet your needs from discovery to commercial launch. Our experienced chemistry team has a proven track record for excellence in the development, scale-up and manufacturing of small molecule drugs, and our modern complex in Concord, Ohio, includes kilo labs and a pilot plant for flexible manufacturing capacities ranging from 22 to 3,000 liters. All services are provided with the highest quality standards and full regulatory support.

 

Ricerca's chemical development capabilities include:

 

  • SAR studies and lead optimization

  • Focused libraries and custom synthesis

  • Method development, validation and release testing

  • Salt screening and polymorph studies

  • Stability studies

  • Process research and development

  • Critical process parameter assessment

  • Radiosynthesis

  • Scale-up and process validation

  • API production with cGMP controls

Capacity

Process Research Laboratories

  • General purpose – mg to kg 
  • Processing scale – up to 12 liters  
  • Pressure range: FV to 50 psig 
  • Temperature range: -78 to +200 ºC

Radiochemistry Labs (4)

  • Licensed for 3H, 14C, 32P, 35S, 131I, 125I, 99Tc, 36Cl
  • cGMP synthesis and blending capabilities

cGMP Kilo Labs (4)

  • HEPA-filtered air system
  • Processing scale – up to 50 liters 
  • Temperature range: -78 to +200 ºC 
  • Dedicated single project use

General Purpose Kilo Labs (6)

  • Pilot Plant Reaction Equipment
    • 17 reactor systems with a total capacity of 17,000 liters
    • Glass and steel reactors
    • Temperature range: -29 to +300 ºC (some systems can go as low as -60 ºC)
  • Instrumentation
    • LC-MS, LC-MS/MS (analytical, semi-prep, and prep)
    • HPLC (analytical, semi-prep, and prep)
    • IR, UV-Vis, DSC, TGA, Polarimetry
    • Bruker Avance III 400 MHz NMR (1H, 13C, 19F, 31P, COSY, NOESY, ROESY, HMBC and HMQC)
    • Parallel reactors
    • Speed vac
    • Automated flash purification (mg to g)
    • Small molecule X-ray crystallography
    • Microwave reactor