Agrochemical Biology

Gaining regulatory approval for new agrochemical compounds requires a broad range of capabilities as well as expert guidance from experienced professionals. With over 25 years of experience in registering agrochemicals, Ricerca provides assistance in all stages of product development, from efficacy determination to final regulatory submission. Our regulatory consultants can advise you with all aspects of EPA-FIFRA, FDA-CVM, OECD, JMAFF, PMRA or other global regulatory acceptance.

 

Our advanced mass spectrometry laboratory offers state-of-the-art LC-MS/MS to rapidly and reliably analyze bioanalytical samples in compliance with the GLP requirements and ICH guidelines.

 

Whether your interest is in plant or animal compounds, Ricerca is the partner of choice for virtual, small and medium-sized agriculture, biotech and veterinary pharmaceutical companies seeking entry into the global marketplace.

 

Ricerca's animal biology capabilities include:


  • Animal metabolism
    • Species: rat, goat and chicken
    • Absorption, distribution and excretion
    • Single and multiple dose
    • Oral, dermal, IP and IV
    • Special surgical techniques (bile duct cannulation; jugular cannulation)
    • Metabolite identification and quantitation
  • Magnitude of the residue
    • Livestock feeding studies (cattle and poultry)
    • Market basket surveys 
    • Independent Laboratory Validations (ILV) 
    • Worker exposure
  • Toxicology
    • Subchronic
      •  21- and 90-day dermal
      • 90-day gavage
      • 90-day dietary
  • Chronic toxicity/oncogenicity
  • Immunotoxicology
  • Reproductive toxicology
  • Neurotoxicity
    • Developmental
    • Functional observation battery
    • Motor activity assessment
  • Target animal safety
  • Facilities
    • GLP-compliant
    • Fully accredited by the Association for Accreditation and Advancement of Laboratory Animal Care (AAALAC) International
    • 43 animal rooms in secure facility with card key and cipher lock entry and complete emergency backup protection
    • Necropsy laboratory and DACVP pathologist
    • Histology laboratory
    • Automated data collection
    • Computerized, site-wide test compound receipt and control system
    • Computerized and controlled environmental monitoring

Ricerca's plant biology capabilities include:

 

  • Environmental fate/residue chemistry
    • Degradation (hydrolysis, photodegradation)
    • Aerobic and anaerobic metabolism (soil and aquatic)
    • Mobility (absorption/desorption, soil column leaching and lab volatility)
    • Prospective/retrospective groundwater
    • Fish bioaccumulation (metabolite identification)
    • Confined accumulation (rotational crop)
    • Field rotational crop
  • Nature of the residue
    • Plant metabolism
    • Metabolite identification
    • Distribution studies
    • Reincorporation methodology (14C) 
  • Magnitude of the residue
    • Crop field trials and storage stability
    • Market basket surveys
    • Independent Laboratory Validations (ILV)