Bioanalytical

Using state-of-the-art LC-MS/MS, experienced Ricerca scientists and technicians rapidly and reliably identify compounds, providing the top-quality data you need to select and develop your drug candidates. Using your validated method, one of our 400 validated assays or one that we develop for you, we analyze bioanalytical samples in compliance with the FDA's Good Laboratory Practice (GLP) requirements and current ICH guidelines.

 

Ricerca’s bioanalytical services include:

 

Bioanalytical Services  

  • Sample analysis for non-clinical and clinical studies
  • LC-MS/MS method development and validation
  • Discovery PK study support for seven day turnaround
  • Dried blood spot assays
  • ELISA for biomolecules
  • WinNonlin and Watson LIMS Software

Metabolite Profiling

  • Metabolite profiling and structure elucidation

  • In vivo studies with or without radiolabeled test article

  • Mass balance
  • Tissue distribution

In Vitro Metabolism

  • Protein binding
  • Plasma stability
  • Stability in liver microsomes and hepatocytes
  • CYP Inhibition, induction and reaction phenotyping

  • In vitro metabolite profiling and identification

Pharmacokinetics (PK) & Toxicokinetics (TK)

  • Bioavailability
  • Formulation selection
  • Bioequivalence (BE)
  • TK support for single and multiple dose toxicology studies